Serious about weight
The GLP-1 medicines behind the weight-loss wave — the best-proven peptides on this whole site
How strong is the science here?
Backed by solid human trials, or used as an approved medicine for specific conditions.
Probably not your path if…
- People looking for a gentle supplement (these are real medicines)
- Anyone expecting results without appetite and stomach side effects
- Using gray-market vials instead of prescribed, quality-controlled products
Compounds to explore
- Clinical evidence
Semaglutide
A GLP-1 medicine widely used for type 2 diabetes and weight management under brand names.
- Clinical evidence
Tirzepatide
A weekly injectable medicine studied and approved for type 2 diabetes and weight management (brand drugs exist).
- Clinical evidence
Cagrilintide
A long-acting amylin-like shot studied for weight loss, sometimes with semaglutide.
Who this is for
You want to lose real weight and you care that it actually works in people — not just in theory. This is the corner of the peptide world with by far the strongest human evidence: large trials, approved medicines, and results you can trust.
How to think about it
These are prescription drugs, not casual supplements. They work mainly by turning down appetite, so weight comes off — but nausea and other stomach effects are common, especially early. Semaglutide (Ozempic/Wegovy) is the well-proven baseline; tirzepatide (Mounjaro/Zepbound) tends to work even better; cagrilintide hits a second appetite hormone and is being paired with semaglutide for even bigger results.
Start here
Read the Lean & Cut stack, then each compound's page for real dosing and side effects. Then talk to a clinician — these belong in a supervised plan.
Clues that match this profile
We’ll use these later for a short guided quiz.
- Main goal is losing a meaningful amount of weight
- Wants the option with the strongest human evidence
- Curious about Ozempic / Mounjaro / Wegovy and what's next